![]() Natural plants have been used to prevent and to treat various diseases for thousands of years. The authors wish to expand this research area not only for their scientific soundness, but also for their potential druggability. Pharmaceutical developmental challenges and opportunities in bringing the phytochemicals into the market are also explored. Relevant molecular mechanisms involved in the pharmacological effects of these phytochemicals are discussed. ![]() This review summarizes the latest research in cancer chemoprevention and treatment using the bioactive components from natural plants. Cancer chemoprevention with natural phytochemical compounds is an emerging strategy to prevent, impede, delay, or cure cancer. Hence, continued searching for a safer and more effective chemoprevention and treatment is clearly needed for the improvement of the efficiency and to lower the treatment cost for cancer care. However, advanced metastasized cancer remains untreatable. The advent of modern drug-targeted therapies has undeniably improved cancer patients’ cares. Cancer remains to be one of the leading causes of death in the United States and around the world.
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